Michael Leitges

• Carracedo, Sergio; Braun, Ursula Barbara & Leitges, Michael (2013). Expression pattern of protein kinase C delta during mouse embryogenesis. BMC Developmental Biology.  ISSN 1471-213X.  13 . doi: 10.1186/1471-213X-13-2
• Hartleben, Björn; Widmeier, Eugen; Suhm, Martina; Worthmann, Kirstin; Schell, Christoph; Helmstadter, Martin; Wiech, Thorsten; Walz, Gerd; Leitges, Michael; Schiffer, Mario & Huber, Tobias B. (2013). aPKC lambda/iota and aPKC zeta Contribute to Podocyte Differentiation and Glomerular Maturation. Journal of the American Society of Nephrology.  ISSN 1046-6673.  24(2), s 253- 267 . doi: 10.1681/ASN.2012060582
• Lutzny, Gloria; Kocher, Thomas; Schmidt-Supprian, Marc; Rudelius, Martina; Klein-Hitpass, Ludger; Finch, Andrew J.; Durig, Jan; Wagner, Michaela; Haferlach, Claudia; Kohlmann, Alexander; Schnittger, Susanne; Seifert, Marc; Wanninger, Stefan; Zaborsky, Nadja; Oostendorp, Robert; Ruland, Jürgen; Leitges, Michael; Kuhnt, Toni; Schäfer, Yvonne; Lampl, Benedikt; Peschel, Christian; Egle, Alexander & Ringshausen, Ingo (2013). Protein Kinase C-beta-Dependent Activation of NF-kappa B in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. Cancer Cell.  ISSN 1535-6108.  23(1), s 77- 92 . doi: 10.1016/j.ccr.2012.12.003
• Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F.; Castilla, Elias A.; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M.; Plas, David R.; Riedl, Stefan J.; Leitges, Michael; Díaz-Meco, Maria Teresa; Richardson, Adam D. & Moscat, Jorge (2013). Control of Nutrient Stress-Induced Metabolic Reprogramming by PKC zeta in Tumorigenesis. Cell.  ISSN 0092-8674.  152(3), s 599- 611 . doi: 10.1016/j.cell.2012.12.028
• Meisel, Marlies; Hermann-Kleiter, Natascha; Hinterleitner, Reinhard; Gruber, Thomas; Wachowicz, Katarzyna; Pfeifhofer-Obermair, Christa; Fresser, Friedrich; Leitges, Michael; Soldani, Cristiana; Viola, Antonella; Kaminski, Sandra & Baier, Gottfried (2013). The Kinase PKC alpha Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses. Immunity.  ISSN 1074-7613.  38(1), s 41- 52 . doi: 10.1016/j.immuni.2012.09.021
• Seidl, Sebastian; Braun, Ursula Barbara; Roos, Norbert; Shaohua, Li; Lüdtke, Timo H.-W.; Kispert, Andreas & Leitges, Michael (2013). Phenotypical Analysis of Atypical PKCs In Vivo Function Display a Compensatory System at Mouse Embryonic Day 7.5. PLoS ONE.  ISSN 1932-6203.  8(5) . doi: 10.1371/journal.pone.0062756
• Thuille, Nikolaus; Wachowicz, Katarzyna; Hermann-Kleiter, Natascha; Kaminski, Sandra; Fresser, Friedrich; Lutz-Nicoladoni, C; Leitges, Michael; Thome, Margot; Massoumi, Ramin & Baier, Gottfried (2013). PKC theta/beta and CYLD Are Antagonistic Partners in the NF kappa B and NFAT Transactivation Pathways in Primary Mouse CD3(+) T Lymphocytes. PLoS ONE.  ISSN 1932-6203.  8(1) . doi: 10.1371/journal.pone.0053709
• Wang, Qiang; Lu, Jinhua; Zhang, Shuang; Wang, Shumin; Wang, Weixiang; Wang, Bing-Yan; Wang, Fengchao; Chen, Qi; Duan, Enkui; Leitges, Michael; Kispert, Andreas & Wang, Haibin (2013). Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice. Biology of Reproduction.  ISSN 0006-3363.  88(1) . doi: 10.1095/biolreprod.112.104687
• Chu, YunXiang; Fioravante, Diasynou; Thanawala, Monica; Leitges, Michael & Regehr, Wade G. (2012). Calcium-Dependent Isoforms of Protein Kinase C Mediate Glycine-Induced Synaptic Enhancement at the Calyx of Held. Journal of Neuroscience.  ISSN 0270-6474.  32(40), s 13796- 13804 . doi: 10.1523/JNEUROSCI.2158-12.2012
• Fioravante, Diasynou; Myoga, Michael H.; Leitges, Michael & Regehr, Wade G. (2012). Adaptive Regulation Maintains Posttetanic Potentiation at Cerebellar Granule Cell Synapses in the Absence of Calcium-Dependent PKC. Journal of Neuroscience.  ISSN 0270-6474.  32(38), s 13004- 13009 . doi: 10.1523/JNEUROSCI.0683-12.2012
• García-Hoz, Carlota; Sánchez-Fernández, Guzmán; García-Escudero, Ramón; Fernández-Velasco, María; Palacios-García, Julia; Ruiz-Meana, Marisol; Díaz-Meco, Maria Teresa; Leitges, Michael; Moscat, Jorge; García-Dorado, David; Boscá, Lisardo; Mayor, Federico, Jr. & Ribas, Catalina (2012). Protein Kinase C (PKC) zeta-mediated G alpha(q) Stimulation of ERK5 Protein Pathway in Cardiomyocytes and Cardiac Fibroblasts. Journal of Biological Chemistry.  ISSN 0021-9258.  287(10), s 7792- 7802 . doi: 10.1074/jbc.M111.282210
• Gong, Jianli; Hoyos, Beatrice; Acin-Perez, Rebeca; Vinogradov, Valerie; Shabrova, Elena; Zhao, Feng; Leitges, Michael; Fischman, Donald A.; Manfredi, Giovanni & Hammerling, Ulrich (2012). Two protein kinase C isoforms, delta and epsilon, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex. The FASEB Journal.  ISSN 0892-6638.  26(8), s 3537- 3549 . doi: 10.1096/fj.11-197376
• Lu, X; Li, N; Shushakova, N; Schmitt, R; Menne, J; Susnik, N; Meier, M; Leitges, Michael; Haller, H; Gueler, F & Rong, S (2012). C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion. JN. Journal of Nephrology (Milano. 1992).  ISSN 1121-8428.  25(5), s 738- 743 . doi: 10.5301/jn.5000053
• Mima, Akira; Kitada, Munehiro; Geraldes, Pedro; Li, Qian; Matsumoto, Motonobu; Mizutani, Koji; Qi, Weier; Li, Chenzong; Leitges, Michael; Rask-Madsen, Christian & King, George L. (2012). Glomerular VEGF resistance induced by PKC beta/SHP-1 activation and contribution to diabetic nephropathy. The FASEB Journal.  ISSN 0892-6638.  26(7), s 2963- 2974 . doi: 10.1096/fj.11-202994
• Rabe, Tamara I.; Griesel, Gundula; Blanke, Stephen; Kispert, Andreas; Leitges, Michael; van der Zwaag, Bert; Burbach, J. Peter H.; Varoqueaux, Frédérique & Mansouri, Ahmed (2012). The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Development.  ISSN 1749-8104.  7 . doi: 10.1186/1749-8104-7-39
• Raddatz, K.; Frangioudakis, G; Diakanastasis, B; Liao, B. M.; Leitges, Michael & Schmitz-Peiffer, Carsten (2012). Deletion of protein kinase C epsilon in mice has limited effects on liver metabolite levels but alters fasting ketogenesis and gluconeogenesis. Diabetologia.  ISSN 0012-186X.  55(10), s 2789- 2793 . doi: 10.1007/s00125-012-2647-5
• Sajan, Mini P.; Nimal, Sonali; Mastorides, Stephen; Acevedo-Duncan, Mildred; Kahn, C. Ronald; Fields, Alan P.; Braun, Ursula Barbara; Leitges, Michael & Farese, Robert V. (2012). Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-i. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  61(4), s 459- 469 . doi: 10.1016/j.metabol.2011.12.008
• Scotti, ML; Smith, KE; Butler, AM; Calcagno, SR; Crawford, HC; Leitges, Michael; Fields, AP & Murray, NR (2012). Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia. PLoS ONE.  ISSN 1932-6203.  7(2) . doi: 10.1371/journal.pone.0030509
• Seidl, Sebastian; Braun, Ursula Barbara & Leitges, Michael (2012). Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling. Biology Open.  ISSN 2046-6390.  1, s 436- 445 . doi: 10.1242/bio.2012505
• Strasser, Dominikus; Neumann, Konstantin; Bergmann, Hanna; Marakalala, Mohlopheni J.; Guler, Reto; Rojowska, Anna; Hopfner, Karl-Peter; Brombacher, Frank; Urlaub, Henning; Baier, Gottfried; Brown, Gordon D.; Leitges, Michael & Ruland, Jürgen (2012). Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-delta to Elicit Card9 Adaptor-Mediated Innate Immunity. Immunity.  ISSN 1074-7613.  36(1), s 32- 42 . doi: 10.1016/j.immuni.2011.11.015
• Bezy, Oliver; Tran, Thien T.; Pihlajamaki, Jussi; Suzuki, Ryo; Emanuelli, Brice; Winnay, Jonathan; Mori, M.; Haas, Joel E; Biddinger, Sudha B.; Leitges, Michael; Goldfine, Allison B.; Patti, Mary Elizabeth; King, George L. & Kahn, C Ronald (2011). PKC delta regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. Journal of Clinical Investigation.  ISSN 0021-9738.  121(6), s 2504- 2517 . doi: 10.1172/JCI46045
• Calcagno, Shelly R.; Li, Shuhua; Shahid, Muhammad W.; Wallace, Michael B.; Leitges, Michael; Fields, Alan P. & Murray, Nicole R. (2011). Protein Kinase C Iota in the Intestinal Epithelium Protects Against Dextran Sodium Sulfate-induced Colitis. Inflammatory Bowel Diseases.  ISSN 1078-0998.  17(8), s 1685- 1697 . doi: 10.1002/ibd.21547
• Cantley, J.; Boslem, E.; Laybutt, D. R.; Cordery, D. V.; Pearson, G.; Carpenter, L.; Leitges, Michael & Biden, T. J. (2011). Deletion of protein kinase C delta in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo. Diabetologia.  ISSN 0012-186X.  54(2), s 380- 389 . doi: 10.1007/s00125-010-1962-y
• Cisse, Moustapha; Braun, Ursula Barbara; Leitges, Michael; Fisher, Abraham; Pages, Gilles; Checler, Frédéric & Vincent, Bruno (2011). ERK1-independent alpha-secretase cut of beta-amyloid precursor protein via M1 muscarinic receptors and PKC alpha/epsilon. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  47(3), s 223- 232 . doi: 10.1016/j.mcn.2011.04.008
• Fioravante, Diasynou; Chu, YunXiang; Myoga, Michael H.; Leitges, Michael & Regehr, Wade G. (2011). Calcium-Dependent Isoforms of Protein Kinase C Mediate Posttetanic Potentiation at the Calyx of Held. Neuron.  ISSN 0896-6273.  70(5), s 1005- 1019 . doi: 10.1016/j.neuron.2011.04.019
• Guler, Reto; Afshar, Mona; Arendse, Berenice; Parihar, Suraj P.; Revaz-Breton, Melanie; Leitges, Michael; Schwegmann, Anita & Brombacher, Frank (2011). PKC delta regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis. European Journal of Immunology.  ISSN 0014-2980.  41(3), s 706- 715 . doi: 10.1002/eji.201040985
• Konopatskaya, Olga; Matthews, Sharon A.; Harper, Matthew T.; Gilio, Karen; Cosemans, Judith M.E.M.; Williams, Christopher; Navarro, Maria N.; Carter, Deborah A.; Heemskerk, Johan W.M.; Leitges, Michael; Cantrell, Doreen & Poole, Alastair W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood.  ISSN 0006-4971.  118(2), s 416- 424 . doi: 10.1182/blood-2010-10-312199
• Limnander, Andre; Depeille, Philippe; Freedman, Tanya S.; Liou, Jen; Leitges, Michael; Kurosaki, Tomohiro; Roose, Jeroen P. & Weiss, Alan Lukasz (2011). STIM1, PKC-delta and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nature Immunology.  ISSN 1529-2908.  12(5), s 425- U81 . doi: 10.1038/ni.2016
• O'Neill, Audrey K.; Gallegos, Lisa L.; Justilien, Verline; Garcia, Erin L.; Leitges, Michael; Fields, Alan P.; Hall, Randy A. & Newton, Alexandra C. (2011). Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1).. Journal of Biological Chemistry.  ISSN 0021-9258.  286(50), s 43559- 43568 . doi: 10.1074/jbc.M111.294603
• Qi, Yanmei; Liu, Jie; Wu, Xunwei; Brakebusch, Cord; Leitges, Michael; Han, Yaling; Corbett, Siobhan A.; Lowry, Stephen F.; Graham, Alan M. & Li, Shaohua (2011). Cdc42 Controls Vascular Network Assembly Through Protein Kinase C iota During Embryonic Vasculogenesis. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  31(8), s 1861- U342 . doi: 10.1161/ATVBAHA.111.230144
• Raddatz, K.; Turner, Nicholas; Frangioudakis, G.; Liao, B. M.; Pedersen, D. J.; Cantley, J.; Wilks, D.; Preston, E.; Hegarty, B. D.; Leitges, Michael; Raftery, Martin; Biden, T. J. & Schmitz-Peiffer, Carsten (2011). Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice. Diabetologia.  ISSN 0012-186X.  54(6), s 1447- 1456 . doi: 10.1007/s00125-011-2073-0
• Sengupta, Amitava; Duran, Angeles; Ishikawa, Eri; Florian, Maria Carolina; Dunn, Susan K.; Ficker, Ashley M.; Leitges, Michael; Geiger, Hartmut; Diaz-Meco, Maria; Moscat, Jorge & Cancelas, Jose A. (2011). Atypical protein kinase C (aPKC zeta and aPKC lambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proceedings of the National Academy of Science of the United States of America.  ISSN 0027-8424.  108(24), s 9957- 9962 . doi: 10.1073/pnas.1103132108
• Thomassen, Martin; Rose, Adam J.; Jensen, Thomas E.; Maarbjerg, Stine J.; Bune, Laurids; Leitges, Michael; Richter, Erik A.; Bangsbo, Jens & Nordsborg, Nikolai B. (2011). Protein kinase C alpha activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle. American Journal of Physiology. Regulatory Integrative and Comparative Physiology.  ISSN 0363-6119.  301(6), s R1808- R1814 . doi: 10.1152/ajpregu.00066.2011
• Zhao, C; Leitges, Michael & Gereau, RW (2011). Isozyme-specific Effects of Protein Kinase C in Pain Modulation. Anesthesiology.  ISSN 0003-3022.  115(6), s 1261- 1270 . doi: 10.1097/ALN.0b013e3182390788
• Acin-Perez, Rebeca; Hoyos, Beatrice; Gong, Jianli; Vinogradov, Valerie; Fischman, Donald A.; Leitges, Michael; Borhan, Babak; Starkov, Anatoly; Manfredi, Giovanni & Hammerling, Ulrich (2010). Regulation of intermediary metabolism by the PKC delta signalosome in mitochondria . The FASEB Journal.  ISSN 0892-6638.  24(12), s 5033- 5042 . doi: 10.1096/fj.10-166934
• Calcagno, SR; Li, Shuhua; Shahid, Muhammad W.; Wallace, Michael B.; Leitges, Michael; Fields, Alan P. & Murray, Nicole R. (2010). Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis . Journal of Crohn's and Colitis.  ISSN 1197-4982. . doi: 10.1002/ibd.21547
• Langlet, Christelle; Springael, Cecile; Johnson, Jolyn; Thomas, Severine; Flamand, Veronique; Leitges, Michael; Goldman, Michel; Aksoy, Ezra & Willems, Fabienne (2010). PKC-α controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells . European Journal of Immunology.  ISSN 0014-2980.  40(2), s 505- 515 . doi: 10.1002/eji.200939391
• Lee, Sang Jun; Kim, Ji Young; Nogueiras, Ruben; Linares, JF; Perez-Tilve, Diego; Jung, Dae Young; Ko, Hwi Jin; Hofmann, Susanna M.; Drew, Angela; Leitges, Michael; Kim, Jason K.; Tschop, Matthias H.; Diaz-Meco, MT & Moscat, J (2010). PKC zeta-Regulated Inflammation in the Nonhematopoietic Compartment Is Critical for Obesity-Induced Glucose Intolerance. Cell Metabolism.  ISSN 1550-4131.  12(1), s 65- 77 . doi: 10.1016/j.cmet.2010.05.003
• Acin-Perez, Rebeca; Hoyos, Beatrice; Zhao, Feng; Vinogradov, Valerie; Fischman, Donald A.; Harris, Robert A.; Leitges, Michael; Wongsiriroj, Nuttaporn; Blaner, William S.; Manfredi, G & Hammerling, Ulrich (2010). Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis. The FASEB Journal.  ISSN 0892-6638.  24(2), s 627- 636 . doi: 10.1096/fj.09-142281
• Deng, Pan-Yue; Xiao, Zhaoyang; Jha, Archana; Ramonet, David; Matsui, Toshimitsu; Leitges, Michael; Shin, Hee-Sup; Porter, JA; Geiger, Jonathan D. & Lei, Saobo (2010). Cholecystokinin Facilitates Glutamate Release by Increasing the Number of Readily Releasable Vesicles and Releasing Probability. Journal of Neuroscience.  ISSN 0270-6474.  30(15), s 5136- 5148 . doi: 10.1523/JNEUROSCI.5711-09.2010
• Gilio, Karen; Harper, Matthew T.; Cosemans, Judith M.E.M.; Konopatskaya, Olga; Munnix, Imke C.A.; Prinzen, Lenneke; Leitges, Michael; Liu, Qinghang; Molkentin, JD; Heemskerk, Johan W.M. & Poole, Alastair W. (2010). Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen. Journal of Biological Chemistry.  ISSN 0021-9258.  285(30), s 23408- 23417 . doi: 10.1074/jbc.M110.136176
• Louie, CM; Caridi, G; Lopes, VS; Brancati, F; Kispert, A; Lancaster, MA; Schlossman, AM; Otto, EA; Leitges, Michael; Grone, HJ; Lopez, I; Gudiseva, HV; O'Toole, JF; Vallespin, E; Ayyagari, R; Ayuso, C; Cremers, FPM; den Hollander, AI; Koenekoop, RK; Dallapiccola, B; Ghiggeri, GM; Hildebrandt, F; Valente, EM; Williams, DS & Gleeson, JG (2010). AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nature Genetics.  ISSN 1061-4036.  42(2), s 175- U117 . doi: 10.1038/ng.519
• Panchatcharam, Manikandan; Miriyala, Sumitra; Yang, Fanmuyi; Leitges, Michael; Chrzanowska-Wodnicka, Magdalena; Quilliam, Lawrence A.; Anaya, Paul; Morris, Andrew J. & Smyth, Susan S. (2010). Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta 3 integrin signaling. International Journal of Biochemistry and Cell Biology.  ISSN 1357-2725.  42(6), s 965- 974 . doi: 10.1016/j.biocel.2010.02.009
• Ruether, Klaus; Feigenspan, Andreas; Pirngruber, Judith; Leitges, Michael; Baehr, Wofgang & Strauss, Olaf (2010). PKC alpha Is Essential for the Proper Activation and Termination of Rod Bipolar Cell Response. Investigative Ophthalmology and Visual Science.  ISSN 0146-0404.  51(11), s 6051- 6058 . doi: 10.1167/iovs.09-4704
• Tossidou, I; Teng, BN; Menne, J; Shushakova, N; Park, Joon-Keun; Becker, JU; Modde, F; Leitges, Michael; Haller, H & Schiffer, M (2010). Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis. PLoS ONE.  ISSN 1932-6203.  5(4) . doi: 10.1371/journal.pone.0010185
• Cantley, J; Burchfield, JG; Pearson, GL; Schmitz-Peiffer, C; Biden, TJ & Leitges, Michael (2009). Deletion of PKC epsilon Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse beta-Cells. Diabetes.  ISSN 0012-1797.  58(8), s 1826- 1834 . doi: 10.2337/db09-0132
• Chen, R; Furman, CA; Zhang, MJ; Kim, MN; Gereau, RW; Leitges, Michael & Gnegy, ME (2009). Protein Kinase C beta Is a Critical Regulator of Dopamine Transporter Trafficking and Regulates the Behavioral Response to Amphetamine in Mice. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565.  328(3), s 912- 920 . doi: 10.1124/jpet.108.147959
• Fehrenbach, Kerstin; Lessmann, Eva; Zorn, Carolin N; Kuhny, Marcel; Grochowy, Gordon; Krystal, Gerard; Leitges, Michael & Huber, Michael (2009). Steel Factor Enhances Supraoptimal Antigen-Induced IL-6 Production from Mast Cells via Activation of Protein Kinase C-beta. Journal of Immunology.  ISSN 0022-1767.  182(12), s 7897- 7905 . doi: 10.4049/jimmunol.0801773
• Fernandez-Marcos, PJ; Abu-Baker, S; Joshi, J; Galvez, A; Castilla, EA; Canamero, M; Collado, M; Saez, C; Moreno-Bueno, G; Palacios, J; Leitges, Michael; Serrano, M; Moscat, J & Diaz-Meco, MT (2009). Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappa B activation and invasive prostate carcinoma. Proceedings of the National Academy of Science of the United States of America.  ISSN 0027-8424.  106(31), s 12962- 12967 . doi: 10.1073/pnas.0813055106
• Fields, AP; Calcagno, SR; Krishna, M; Rak, S; Leitges, Michael & Murray, NR (2009). Protein Kinase C beta Is an Effective Target for Chemoprevention of Colon Cancer. Cancer Research.  ISSN 0008-5472.  69(4), s 1643- 1650 . doi: 10.1158/0008-5472.CAN-08-3187
• Frangioudakis, G; Burchfield, JG; Narasimhan, S; Cooney, GJ; Leitges, Michael; Biden, TJ & Schmitz-Peiffer, C (2009). Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta. Diabetologia.  ISSN 0012-186X.  52(12), s 2616- 2620 . doi: 10.1007/s00125-009-1543-0
• Galvez, AS; Duran, A; Linares, JF; Pathrose, P; Castilla, EA; Abu-Baker, S; Leitges, Michael; Diaz-Meco, MT & Moscat, J (2009). Protein Kinase C zeta Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo. Molecular and Cellular Biology.  ISSN 0270-7306.  29(1), s 104- 115 . doi: 10.1128/MCB.01294-08
• Geraldes, P; Hiraoka-Yamamoto, J; Matsumoto, M; Clermont, A; Leitges, Michael; Marette, A; Aiello, LP; Kern, TS & King, GL (2009). Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nature Medicine.  ISSN 1078-8956.  15(11), s 1298- U133 . doi: 10.1038/nm.2052
• Gruber, T; Hermann-Kleiter, N; Pfeifhofer-Obermair, C; Lutz-Nicoladoni, C; Thuille, N; Letschka, T; Barsig, J; Baudler, M; Li, JP; Metzler, B; Nusslein-Hildesheim, B; Wagner, J; Leitges, Michael & Baier, G (2009). PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo. Molecular Immunology.  ISSN 0161-5890.  46(10), s 2071- 2079 . doi: 10.1016/j.molimm.2009.02.030
• Harja, E; Chang, JS; Lu, Y; Leitges, Michael; Zou, YS; Schmidt, AM & Yan, SF (2009). Mice deficient in PKC beta and apolipoprotein E display decreased atherosclerosis. The FASEB Journal.  ISSN 0892-6638.  23(4), s 1081- 1091 . doi: 10.1096/fj.08-120345
• Huber, TB; Hartleben, B; Winkelmann, K; Schneider, L; Becker, JU; Leitges, Michael; Walz, G; Haller, H & Schiffer, M (2009). Loss of Podocyte aPKC lambda/iota Causes Polarity Defects and Nephrotic Syndrome. Journal of the American Society of Nephrology.  ISSN 1046-6673.  20(4), s 798- 806 . doi: 10.1681/ASN.2008080871
• Jensen, TE; Maarbjerg, SJ; Rose, AJ; Leitges, Michael & Richter, EA (2009). Knockout of the predominant conventional PKC isoform, PKC alpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake. American Journal of Physiology. Endocrinology and Metabolism.  ISSN 0193-1849.  297(2), s E340- E348 . doi: 10.1152/ajpendo.90610.2008
• Liu, QH; Chen, XW; MacDonnell, SM; Kranias, EG; Lorenz, JN; Leitges, Michael; Houser, SR & Molkentin, JD (2009). Protein Kinase C alpha, but Not PKC beta or PKC gamma, Regulates Contractility and Heart Failure Susceptibility Implications for Ruboxistaurin as a Novel Therapeutic Approach. Circulation Research.  ISSN 0009-7330.  105(2), s 194- 200 . doi: 10.1161/CIRCRESAHA.109.195313
• Madigan, JP; Bodemann, BO; Brady, DC; Dewar, BJ; Keller, PJ; Leitges, Michael; Philips, MR; Ridley, AJ; Der, CJ & Cox, AD (2009). Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochemical Journal.  ISSN 0264-6021.  424, s 153- 161 . doi: 10.1042/BJ20082377
• Murray, NR; Weems, J; Braun, Ursula Barbara; Leitges, Michael & Fields, AP (2009). Protein Kinase C beta II and PKC iota/lambda: Collaborating Partners in Colon Cancer Promotion and Progression. Cancer Research.  ISSN 0008-5472.  69(2), s 656- 662 . doi: 10.1158/0008-5472.CAN-08-3001
• Regala, Roderick P.; Davis, Rebecca K.; Kunz, Alyssa; Khoor, Andras; Leitges, Michael & Fields, Alan P. (2009). Atypical Protein Kinase C iota Is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis. Cancer Research.  ISSN 0008-5472.  69(19), s 7603- 7611 . doi: 10.1158/0008-5472.CAN-09-2066
• Tossidou, I; Starker, G; Krüger, Janna; Meier, M; Leitges, Michael; Haller, H & Schiffer, M (2009). PKC-alpha Modulates TGF-beta Signaling and Impairs Podocyte Survival. Cellular Physiology and Biochemistry.  ISSN 1015-8987.  24(5-6), s 627- 634 . doi: 10.1159/000257518
• Yang, JQ; Leitges, Michael; Duran, A; Diaz-Meco, MT & Moscat, J (2009). Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proceedings of the National Academy of Science of the United States of America.  ISSN 0027-8424.  106(4), s 1099- 1104 . doi: 10.1073/pnas.0805907106
• Zorn, CN; Keck, S; Hendriks, RW; Leitges, Michael; Freudenberg, MA & Huber, M (2009). Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells. Cellular Signalling.  ISSN 0898-6568.  21(1), s 79- 86 . doi: 10.1016/j.cellsig.2008.09.010
• Alfa, Cissé M.; Louis, K.; Braun, Ursula Barbara; Mari, B.; Leitges, Michael; Slack, BE; Fisher, A.; Auberger, P.; Checler, F. & Vincent, B. (2008). Isoform-specific contribution of protein kinase C to prion processing. Molecular and Cellular Neuroscience.  ISSN 1044-7431.  39(3), s 400- 410 . doi: 10.1016/j.mcn.2008.07.013
• Bossi, O.; Gartsbein, M.; Leitges, Michael; Kuroki, T.; Grossman, S. & Tennenbaum, T. (2008). UV irradiation increases ROS production via PKCdelta signaling in primary murine fibroblasts.. Journal of Cellular Biochemistry.  ISSN 0730-2312.
• Cameron, AJ; Procyk, KJ; Leitges, Michael & Parker, PJ (2008). PKCalpha protein but not kinase activity is critical for glioma cell proliferation and survival.. International Journal of Cancer.  ISSN 0020-7136.  123(4), s 769- 779
• Chen, R; Furman, CA; Zharg, M; Kim, MN; Gereau, RW; Leitges, Michael & Gnegy, ME (2008). Protein Kinase C{beta} is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565.
• Galvez, AS; Duran, A; Linares, JF; Pathrose, P; Castilla, EA; Abu-Baker, S; Leitges, Michael; Diaz-Meco, MT & Moscat, J (2008). PKC{zeta} represses the IL-6 promoter and impairs tumorigenesis in vivo.. Molecular and Cellular Biology.  ISSN 0270-7306.
• Harja, E; Chang, JS; Lu, Y; Leitges, Michael; Zou, YS; Schmidt, AM & Yan, SF (2008). Mice deficient in PKC{beta} and apolipoprotein E display decreased atherosclerosis. The FASEB Journal.  ISSN 0892-6638.
• Joshi, J; Fernandez-Marcos, PJ; Galvez, A; Amanchy, R; Linares, JF; Duran, A; Pathrose, P; Leitges, Michael; Canamero, M; Collado, M; Salas, C; Serrano, M; Moscat, J & Diaz-Meco, MT (2008). Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO Journal.  ISSN 0261-4189.  27, s 2181- 2193 . doi: 10.1038/emboj.2008.149
• Kong, L.; Andrassy, M.; Chang, JS; Huang, C.L.; Asai, T.; Szabolcs, MJ; Homma, S.; Liu, R.; Zou, YS; Leitges, Michael; Yan, SD; Ramasamy, R.; Schmidt, AM & Yan, SF (2008). PKC{beta} Modulates Ischemia Reperfusion Injury in the Heart.. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.
• Letschka, T.; Kollmann, V; Pfeifhofer-Obermair, C.; Lutz-Nikoladoni, C.; Obermair, GJ; Fresser, F.; Leitges, Michael; Hermann-Kleiter, N.; Kaminski, S. & Baier, G. (2008). PKC-theta selectively controls the adhesion-stimulating molecule Rap1. Blood.  ISSN 0006-4971.  112(12), s 4617- 4627 . doi: 10.1182/blood-2007-11-121111
• Potok, MA; Cha, KB; Hunt, A.; Brinkmeier, ML; Leitges, Michael; Kispert, A. & Camper, SA (2008). WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.. Developmental Dynamics.  ISSN 1058-8388.  237(4), s 1006- 1020
• Poussin, MA; Leitges, Michael & Goldfine, H. (2008). The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PCKbeta.. Microbial Pathogenesis.  ISSN 0882-4010.
• Zorn, CN; Keck, S.; Hendriks, RW; Leitges, Michael; Freudenberg, MA & Huber, M. (2008). Bruton's tyosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.. Cellular Signalling.  ISSN 0898-6568.
• Epp, N; Furstenberger, G; Muller, K; de Juanes, S; Leitges, Michael; Hausser, I; Thieme, F; Liebisch, G; Schmitz, G & Krieg, P (2007). 12R-lipoxygenase deficiency disrupts epidermal barrier function. Journal of Cell Biology.  ISSN 0021-9525.  177
• Farese, RV; Sajan, MP; Yang, H; Li, PF; Mastorides, S; Gower, WR; Nimal, S; Choi, CS; Kim, S; Shulman, GI; Kahn, CR; Braun, Ursula Barbara & Leitges, Michael (2007). Muscle-specific knockout of PKC-lambda impairs qlucose transport and induces metabolic and diabetic syndromes. Journal of Clinical Investigation.  ISSN 0021-9738.  117, s 2289- 2301 . doi: 10.1172/JCI31408
• Leitges, Michael (2007). Functional PKC in vivo analysis using deficient mouse models. Biochemical Society Transactions.  ISSN 0300-5127.  35, s 1018- 1020 . doi: 10.1042/BST0351018
• Moulakakis, C; Adam, S; Seitzer, U; Schromm, AB; Leitges, Michael & Stamme, C (2007). Surfactant protein A activation of atypical protein kinase C zeta in I kappa B-alpha-dependent anti-inflammatory immune regulation. Journal of Immunology.  ISSN 0022-1767.  179, s 4480- 4491
• Peirson, SN; Oster, H; Jones, SL; Leitges, Michael; Hankins, MW & Foster, RG (2007). Microarray analysis and functional genomics identify novel components of melanopsin signaling. Current Biology.  ISSN 0960-9822.  17(16), s 1363- 1372 . doi: 10.1016/j.cub.2007.07.045
• Schmitz-Peiffer, C; Laybutt, DR; Burchfield, JG; Gurisik, E; Narasimhan, S; Mitchell, CJ; Pedersen, DJ; Braun, Ursula Barbara; Cooney, GJ; Leitges, Michael & Biden, TJ (2007). Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metabolism.  ISSN 1550-4131.  6, s 320- 328 . doi: 10.1016/j.cmet.2007.08.012
• Schwegmann, A; Guler, R; Cutler, AJ; Arendse, B; Horsnell, WG; Flemming, A; Kottmann, AH; Ryan, G; Hide, W; Leitges, Michael; Seoighe, C & Brombacher, F (2007). Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proceedings of the National Academy of Science of the United States of America.  ISSN 0027-8424.  104(41), s 16251- 16256

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• Niessen, Michaela; Scott, Jeanie; Vorhagen, Susanne; Sotiropoulou, Peggy; Blanpain, Cedric; Leitges, Michael & Niessen, Carien M. (2012). The polarity protein aPKC lambda regulates epidermal cell fate decisions. Journal of Investigative Dermatology.  ISSN 0022-202X.  132, s S80- S80
• Rong, S; Kirsch, T; Shushakova, N; Menne, J; Leitges, Michael; Haller, H & Guler, F (2012). RENAL PKC EPSILON DEFICIENCY ATTENUATES ISCHEMIA REPERFUSION INJURY VIA IMPAIRED NEUTROPHIL INFILATRATION AND TNF ALPHA DEPENDENT APOPTOSIS INHIBITION. Transplant International.  ISSN 0934-0874.  25, s 22- 22
• Worthmann, Kirstin; Leitges, Michael; Dittrich-Breiholz, Oliver; Kracht, Michael; Haller, Hermann & Schiffer, Mario (2012). DEF-6 EXPRESSION AND LOCALIZATION IS CHANGED IN PKC Lambda/I DEFICIENT MICE AND PODOCYTES. Nephrology, Dialysis and Transplantation.  ISSN 0931-0509.  27, s 10- 10
• Thomassen, Martin; Rose, Adam; Jensen, Thomas E.; Maarbjerg, Stine J.; Bune, Laurids; Leitges, Michael; Richter, Erik A.; Bangsbo, Jens & Nordsborg, Nikolai B. (2011). Protein kinase Cα activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle.. American Journal of Physiology.  ISSN 0002-9513.  301(6), s 1808- 1814 . doi: 10.1152/ajpregu.00066.2011
• Fährmann, M; Honisch, S; Kaufhold, MA; Leitges, Michael & Beil, W (2007). Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control.. Biochim Biophys Acta - Molecular Basis of Disease.
• Gruber, T; Fresser, F; Jenny, M; Uberall, F; Leitges, Michael & Baier, G (2007). PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.. Molecular Immunology.  ISSN 0161-5890.  45(1), s 117- 126
• Jakubcakova, V; Oster, H; Tamanini, F; Cadenas, C; Leitges, Michael; van der Horst, GT & Eichele, G (2007). Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism.. Neuron.  ISSN 0896-6273.  54(5), s 831- 843
• Ma, JS; Monu, N; Shen, DT; Mecklenbräuker, I; Radoja, N; Haydar, TF; Leitges, Michael; Frey, AB; Vukmanovic, S & Radoja, S (2007). Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL.. Journal of Immunology.  ISSN 0022-1767.  178(12), s 7814- 7821
• Meier, M; Menne, J; Park, JK; Holtz, M; Gueler, F; Kirsch, T; Schiffer, M; Mengel, M; Lindschau, C; Leitges, Michael & Haller, H (2007). Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo. Journal of the American Society of Nephrology.  ISSN 1046-6673.  4, s 1190- 1198
• Zhao, T; Zhou, X; Szabó, N; Leitges, Michael & Alvarez-Bolado, G (2007). Foxb1-driven Cre expression in somites and the neuroepithelium of diencephalon, brainstem, and spinal cord.. Genesis.  ISSN 1526-954X.  45(781), s 781- 787

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